肠道菌群在非酒精性脂肪肝发生发展中的作用机制 [中文引用][英文引用]

非酒精性脂肪肝是代谢综合征的肝脏表现，可发展为肝硬化和肝癌。非酒精性脂肪肝的病因尚未明确，近年来宿主肠道微生物在非酒精性脂肪肝的发生、发展及治疗中的作用越来越受到重视。目前认为人类肠道是一个内在重要的代谢及免疫器官，肠道微生物的组成可影响宿主代谢，改变肠道通透性，引起炎症及一系列免疫反应。本文就肠道微生物在非酒精性脂肪肝的病理生理过程中的作用机制进行综述。

Nonalcoholic fatty liver disease (NAFLD) is a kind of metabolic syndrome, which may develop into cirrhosis and hepatic carcinoma. The etiology of NAFLD is still unclear. Recently, the role of host gut microbiota in occurrence, development and treatment of NAFLD is getting more attention. Human gut can be recognized as an important metabolic and immunological organ. Different composition of gut microbiota can affect host metabolism and cause inflammatory response and a series of immune reaction by changing intestinal permeability. The role of gut microbiota in the pathophysiology of NAFLD is reviewed in this paper.