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期刊名称:中华消化病与影像杂志
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肝纤维化患者FibroTest值的测定及与食管胃静脉曲张分级的关系 [中文引用][英文引用]

Liver Fibrosis Patients’ Determination of FibroTest Value and the Relation Between FibroTest Value and Esophageal and Gastric Varices Grading

作者(英文): 
单位(英文):The First Hospital of Shanxi Medical University 
关键词(英文):Fibrosis liver  Esophageal and gastric varices  Fibrosis model Gastroscopy 
分类号:
出版年·卷·期(页码):2015·5·第6期(280-283)
DOI: 10.3877/cma.j.issn.2095-2015.2015.06.005
-----摘要:-------------------------------------------------------------------------------------------

目的 测定不同程度肝纤维化患者FibroTest值(FT值)并探讨其与食管胃静脉曲张分级的关系。 方法 收集依据《肝纤维化中西医结合诊疗指南》诊断的肝纤维化、肝硬化患者各60例,以同期健康体检者60例作为正常对照组,测定血清相关指标,根据FibroTest模型计算FT值。正常对照组、肝纤维组及肝硬化组中分别有18例、32例和40例行胃镜检查,计算食管胃静脉曲张发生率并对食管胃静脉曲张患者进行内镜下分级。分析食管胃静脉曲张患者FT值与食管胃静脉曲张分级的相关性。 结果 与正常对照组相比,肝纤维化组及肝硬化组FT值升高,有统计学意义(P<0.05),肝纤维化组与肝硬化组之间有统计学差异(P<0.05)。正常对照组未见有食管胃静脉曲张发生,肝纤维化组食管胃静脉曲张发生率与正常对照组相比没有明显差异(P>0.05),肝硬化组食管胃静脉曲张发生率与正常对照组相比升高,有统计学意义(P<0.05),肝纤维化组与肝硬化组之间食管胃静脉曲张发生率有统计学差异(P<0.05)。食管胃静脉曲张患者FT值与食管胃静脉曲张程度成正相关,有统计学意义(P<0.05)。 结论 FT值的测定对临床诊断不同程度的肝纤维化有一定的指导意义,肝纤维化患者FT值的测定对食管胃静脉曲张分级有一定的预测价值。

-----英文摘要:---------------------------------------------------------------------------------------

Objective To determine varying degrees liver fibrosis patients’FibroTest value (FT value) and to explore its relation with esophageal and gastric varices grading. Methods Based on Liver Fibrosis Combination of Chinese Traditional and Western Medicine Diagnosis and Treatment Guidelines, we collected sixty liver fibrosis patients, sixty liver cirrhosis patients and sixty healthy controls. To test serum related indicators and calculate FT value according to FibroTest model. Eighteen healthy controls, thirty-two liver fibrosis patients and forty liver cirrhosis patients accepted gastroscopy. Incidence of esophageal and gastric varices was observed. What’s more, esophageal and gastric varices patients were been differentiated on the basis of endoscopic grading. The relation between FT value and esophageal and gastric varices endoscopic grading was explored.  Results Compared with healthy controls group, liver fibrosis group’ and liver cirrhosis group’ FT value increased statistically (P<0.05). There was statistical difference between liver fibrosis group’ FT value and liver cirrhosis group’ FT value (P<0.05). Esophageal and gastric varices was not been found in healthy controls. Incidence of esophageal and gastric varices in liver cirrhosis patients was higher than healthy controls (P<0.05). However, Incidence of esophageal and gastric varices in liver bibrosis patients was not higher than healthy controls (P>0.05). There was statistical difference between liver fibrosis group’ esophageal and gastric varices incidence and liver cirrhosis group’ esophageal and gastric varices incidence (P<0.05). There was a positive correlation between patients’ FT value and esophageal and gastric varices grading, with statistical significance (P<0.05). Conclusions Determination of FT value has certain guiding significance for diagnosis of varying degrees liver fibrosis. To detect FT value has cetain predictive value for esophageal and gastric varices grading.

-----参考文献:---------------------------------------------------------------------------------------

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若需在您的论文中引用此文,请按以下格式著录参考文献:
中文著录格式: 张海燕 ,,韩轶,刘立新,郭晓红.肝纤维化患者FibroTest值的测定及与食管胃静脉曲张分级的关系.中华消化病与影像杂志(电子版).2015;5(6):280-283.
英文著录格式: .Liver Fibrosis Patients’ Determination of FibroTest Value and the Relation Between FibroTest Value and Esophageal and Gastric Varices Grading.No Title Settings.2015;5(6):280-283.

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