产后精神病患者大脑分数低频振幅的静息态fMRI研究 [中文引用][英文引用]

 [摘要]目的 探讨静息态下产后精神病患者大脑分数低频振幅的变化。方法 本研究采集中国人民解放军联勤保障部队第九六〇医院2020年1月至2021年1月12例产后精神病患者与14例在年龄、母乳喂养、生产方式、受教育程度及是否为初产妇情况与之匹配的志愿者为对照组，利用静息态功能磁共振成像（rs-fMRI）数据进行分析，比较两组受试者全脑的fALFF差异，并分析产后精神病组有显著差异的fALFF值与简明精神病评定量表评分之间的相关性。结果 与对照组相比，产后精神病组海马旁回和扣带回fALLF值显著升高（单个体素P＜0.05，体素值≥55，AlphaSim校正），且均与简明精神病评定量表评分之间无相关性。结论 产后精神病可引起边缘系统神经元异常活动，这有助于理解产后精神病患者的大脑神经功能改变特性。

 [Abstract]  Objective  To investigate the changes of fractional amplitude of low-frequency fluctuation in patients with postpartum psychosis in resting-state. Methods  Twelve patients with postpartum psychosis and 14 volunteers matched with age, breast feeding, mode of production, education and primipara (control group) were collected in the 960th Hospital of PLA Joint Logistics Support Force from January 2020 to January 2021. Resting-state functional magnetic resonance imaging (rs-fMRI) data were used to compare fALFF differences in the whole brain of the two groups, and the correlation between fALFF value of postpartum psychosis group with significant differences and the score of the Brief Psychiatric Rating Scales (BPRS) was analyzed. Results  fALLF values of the parahippocampal gyrus and cingulate gyrus were significantly higher in the postpartum psychosis group than those in the control group (individual voxel P＜0.05, voxel value≥55, AlphaSim correction), and there was no correlation with the BPRS score. Conclusion  Postpartum psychosis can cause aberrant neuronal activity in the limbic system, which is helpful to understand the altered nature of brain neurological function in postpartum psychosis patients.