读者在线:用户名 密码
首页期刊简介投稿须知期刊目录专家风采编委会特约编委特邀顾问广告发行联系我们

喜报

《中华消化病与影像杂志(电子版)》

被中国科技核心期刊(中国科技论文统计源期刊)收录




刊物信息more
期刊名称:中华消化病与影像杂志
              (电子版)
主管单位:中华人民共和国国家
           卫生健康委员会
主办单位:中华医学会
承办单位:山东省第二人民医院(山东省耳鼻喉医院)
总 编 辑: 王宝成   孙钢
 
网 址http://www.zhxhbyyxzz.com
地 址
济南市槐荫区段兴西路4号
        
  中华消化病与影像杂志( 电子版)
编辑部
电 话:0531-83086377
    

邮政编码:250022

电子邮箱:zhxhbyyxzz@126.com
国际标准刊号:ISSN 2095-2015
国内统一刊号:CN 11-9312/R
访问统计
您是第 5844195位浏览者
  您当前的位置:首页 >> 正文

可溶性免疫检查点对胃癌患者免疫治疗疗效和预后的预测价值 [中文引用][英文引用]

Predictive value of efficacy and prognosis of soluble immune checkpoints for immunotherapy in patients with gastric cancer

作者(英文): 
单位(英文): 
分类号:
出版年·卷·期(页码):2023·1·第5期(305-311)
DOI: 10.3877/cma.j.issn.2095-2015.2023.05.007
-----摘要:-------------------------------------------------------------------------------------------

【摘要】目的:探讨可溶性免疫检查点对胃癌患者免疫治疗疗效和预后的预测价值。方法:收集2021年4月至2022年7月在南京医科大学附属常州第二人民医院肿瘤中心接受一线SOX化疗联合PD-1抑制剂的胃癌患者的临床资料,检测治疗前、疾病进展时可溶性免疫检查点sIL-2Ra(CD25)、s4-1BB、sCD86、sCTLA-4、Free Active TGF-β1、sPD-1、sPD-L1、sTIM-3、sLAG-3、sGalectin-9的浓度。利用Mann-Whitney秩和检验比较疗效评价达部分缓解(PR)组与未达PR组[疾病稳定(SD)+疾病进展(PD)]患者治疗前可溶性免疫检查点差异,Logistic回归分析疗效的独立预测因素,Kaplan-Meier及COX回归分析影响预后的可溶性免疫检查点,Wilcoxon 符号秩检验比较治疗前后可溶性免疫检查点的变化。结果:共40例患者纳入分析,17例(42.5%)患者疗效评价为PR,17例(42.5%)为SD,6例(15.0%)为PD。PR组患者治疗前sPD-1、sPD-L1、sGalectin-9浓度显著高于疗效未达PR组患者(6.27pg/mL 比 3.49pg/mL, P=0.0043; 7.96pg/mL 比 7.31pg/mL, P=0.0014; 15083.09pg/mL 比 8533.77pg/mL, P=0.0024)。治疗前血清sPD-1(>4.21pg/mL)浓度高的患者无进展生存期显著延长(P<0.001,HR 0.18, 95%CI 0.08~0.41, P<0.0001),sPD-1是胃癌患者治疗最佳总体疗效(BOR)的独立预测因子。17例患者疾病进展时sCD86较基线显著增高(74.62pg/mL 比 49.71pg/mL, P=0.0038)。结论:sPD-1可作为胃癌患者免疫治疗BOR的预测因子,免疫治疗后sCD86增高可能是免疫治疗耐药的原因。

-----英文摘要:---------------------------------------------------------------------------------------

 [Abstract]  Objective  To explore the predictive value of soluble immune checkpoints for the efficacy and prognosis of immunotherapy in patients with gastric cancer. Methods  From April 2021 to July 2022, clinical data of patients with gastric cancer who received first-line SOX chemotherapy combined with PD-1 inhibitor at the Cancer Center of Changzhou No.2 People's Hospital Affiliated to Nanjing Medical University were collected. Concentrations of sIL-2Ra (CD25), s4-1BB, sCD86, sCTLA-4, Free Active TGF-β1, sPD-1, sPD-L1, sTIM-3, sLAG-3, sGalectin-9 were detected before treatment and at the time of disease progression. Mann-Whitney U test was used to compare the differences of soluble immune checkpoints concentration before treatment between patients with partial response (PR) and those without PR [disease stability (SD)+disease progression (PD)]. Logistic regression analysis was used to explore independent factors of efficacy prediction. Kaplan-Meier and COX regression analysis were used to explore soluble immune checkpoints affecting prognosis, and Wilcoxon signed-rank test was used to compare the changes of soluble immune checkpoints before and after treatment. Results  A total of 40 patients with gastric cancer were incorporated into the analysis, with 17 (42.5%) patients evaluated as PR, 17 (42.5%) as SD, and 6 (15.0%) as PD. Before treatment, the concentrations of sPD-1, sPD-L1, and sGalectin-9 in the PR group were significantly higher than those in the SD+PD group (6.27 pg/ml vs. 3.49 pg/ml, P=0.004 3; 7.96 pg/ml vs. 7.31 pg/ml, P=0.001 4; 15 083.09 pg/ml vs. 8 533.77 pg/ml, P=0.002 4). Patients with high serum sPD-1 concentration before treatment (sPD-1>4.21 pg/ml) showed significantly longer progression free survival (P<0.001, HR=0.18, 95%CI: 0.08-0.41, P<0.000 1). sPD-1 was an independent predictor of best overall response (BOR) in the treatment of gastric cancer patients. Seventeen patients showed a significant increase in sCD86 at the time of disease progression compared to baseline (74.62 pg/ml vs. 49.71 pg/ml, P=0.003 8). Conclusion  sPD-1 can act as a predictive factor for BOR of immunotherapy in gastric cancer patients, and the increase in sCD86 after immunotherapy may be the reason for immunotherapy resistance.

 

-----参考文献:---------------------------------------------------------------------------------------

欢迎阅读《中华消化病与影像杂志(电子版)》!您是该文第 587 位读者!

若需在您的论文中引用此文,请按以下格式著录参考文献:
中文著录格式:
杨镠 ,,秦岚群 ,,耿茜 ,,李栋庆 ,,戚春建 ,,蒋华
.可溶性免疫检查点对胃癌患者免疫治疗疗效和预后的预测价值.中华消化病与影像杂志(电子版).2023;1(5):305-311.
英文著录格式: .Predictive value of efficacy and prognosis of soluble immune checkpoints for immunotherapy in patients with gastric cancer.No Title Settings.2023;1(5):305-311.

与该文相关的文章(仅限于本刊内

已投本刊未发表相似文章

地址:山东济南市槐荫区段兴西路4号,山东省第二人民医院《中华消化病与影像杂志(电子版)》编辑部;

邮政编码:250022;电话:0531-83086377;投稿邮箱:zhxhbyyxzz@126.com  鲁公网安备 37010402001170号

本系统由北京博思汇文数字科技有限公司设计开发 技术服务电话:010-60213898

鲁ICP备18044012号-6